Epitalon
Epitalon is a synthetic tetrapeptide studied for its proposed role in telomerase activity and pineal gland function, making it a frequently referenced compound in aging-related research.
Part of KYIN Peptides' standard catalogue — see the product page for pricing, or paired with Pinealon in our Longevity Bundle.
What Is Epitalon?
Epitalon's research lineage runs back to 1973, when Soviet researchers first described “Epithalamin” — a polypeptide extract from the pineal gland — in published research. The scientist most associated with developing this line of work is Vladimir Khavinson, whose research into extending functional longevity began in the late 1970s under the Soviet military, which was specifically interested in helping soldiers and cosmonauts withstand extreme physiological stress. Alongside collaborator Vladimir Anisimov, Khavinson's research eventually centered at what became the St. Petersburg Institute of Bioregulation and Gerontology. Epitalon itself — a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly — was synthesized to match the amino acid composition identified within Epithalamin, the original bovine pineal-gland extract. See its full discovery history.
Research Focus
Epitalon is now the most extensively studied of the Khavinson-lineage bioregulator peptides, and its research program has stayed close to its original focus on aging and pineal-gland biology. A substantial share of the published literature examines its relationship to telomerase, the enzyme responsible for maintaining the protective caps (telomeres) on chromosomes, since telomere shortening is one of the most-studied mechanisms of cellular aging. It sits in KYIN's Longevity & Cellular Health category alongside SS-31 and NAD+. See our Longevity & Cellular Health research overview, or how it compares to SS-31.
- Telomerase activity research
- Pineal gland / melatonin regulation studies
- Cellular senescence research
Clinical & Preclinical Trial Data
Khavinson and Morozov (2003) followed a cohort of 266 elderly individuals for 6–8 years after receiving short courses of peptide bioregulators, reporting mortality reduction ranging from 1.6× (Epitalon-based regimen alone) up to roughly 4× in the most intensive combined-regimen group, versus untreated controls. This and most other Epitalon research comes from Khavinson's own institute (the St. Petersburg Institute of Bioregulation and Gerontology) and Russian-affiliated journals, and has not been independently replicated in a large Western multi-center trial — it should be read as early domestic cohort evidence, not evidence of the same strength as an FDA-reviewed trial.
In July 2026, an FDA advisory committee recommended Epitalon for the 503A compounding bulks list — a non-binding vote, not FDA drug approval. Read what it actually means →
Availability
Epitalon is part of KYIN Peptides' standard catalogue — see the product page for pricing, or contact us to order.
Epitalon questions
What is Epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson, matching the amino acid composition of Epithalamin, a pineal-gland extract first described by Soviet researchers in 1973. It is studied for its proposed role in telomerase activity and pineal gland function.
Has Epitalon been tested in human trials?
Khavinson and Morozov (2003) followed a cohort of 266 elderly individuals for 6–8 years after receiving short courses of peptide bioregulators, reporting mortality reduction ranging from 1.6× up to roughly 4× versus untreated controls. This and most other Epitalon research comes from Khavinson's own institute and Russian-affiliated journals, and has not been independently replicated in a large Western multi-center trial.
Does KYIN Peptides sell Epitalon?
Yes — Epitalon is part of our standard catalogue, both individually and paired with Pinealon in our Longevity Bundle. See the product page for pricing.
Interested in Epitalon?
See pricing and order on the product page, or browse our other longevity-focused peptides.